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Innovent Presents Part Ib Scientific Information Replace of IBI110 (Anti-LAG-3 Monoclonal Antibody) on the 2022 European Society For Medical Oncology Immuno-Oncology

Innovent Presents Part Ib Scientific Information Replace of IBI110 (Anti-LAG-3 Monoclonal Antibody) on the 2022 European Society For Medical Oncology Immuno-Oncology

ROCKVILLE, Md. and SUZHOU, China, Dec. 8, 2022 /PRNewswire/ — Innovent Biologics, Inc. (“Innovent”) (HKEX: 01801), a world-class biopharmaceutical firm that develops, manufactures and commercializes high-quality medicines for the therapy of oncology, autoimmune, metabolic, ophthalmology and different main ailments, at this time introduced that up to date medical knowledge of IBI110 (anti-LAG-3 monoclonal antibody) in superior squamous non-small cell lung most cancers (sqNSCLC) is introduced on the 2022 European Society for Medical Oncology Immuno-Oncology Congress (ESMO-IO), held Dec 7-9, 2022.

Efficacy and security of IBI110 (anti-LAG-3 mAb) together with Sintilimab (anti-PD-1 mAb) in Superior Squamous Non-small Cell Lung Most cancers (sqNSCLC): Up to date Outcomes from a Part Ib Research

Poster #: 86P

IBI110 is an IgG4κ recombinant human anti-LAG-3 monoclonal antibody developed by Innovent Biologics. The Part Ib research goals to judge the efficacy and security of IBI110 together with sintilimab and chemotherapy (paclitaxel plus carboplatin) as first-line remedy for superior sqNSCLC.

  • 20 therapy naïve sqNSCLC sufferers obtained IBI110 (200 mg, Q3W) mixed with sintilimab and chemotherapy and obtained a minimum of 1 post-baseline tumor evaluation. As of the information cutoff date of Oct 25, 2022, median follow-up time was 12.0 (95% CI, 11.9 -13.1) months, 16 sufferers achieved partial response (PR), the target response price (ORR) was 80%; the 12-month development free survival (PFS) price was 60.0% (95% CI, 35.7-77.6), the median PFS was not reached; the 12-month general survival (OS) price was 85.0% (95% CI, 60.4-94.9) .
  • For security outcomes, the commonest therapy associated adversarial occasions (TRAEs) ≥ grade 3 had been decreased neutrophil depend (30.0%) and decreased white blood cell depend (20.0%). Immune-related AEs (irAEs) occurred in 14 sufferers, through which solely 4 sufferers skilled irAE ≥ grade 3. No treatment-related deaths occurred.
  • IBI110 mixed with sintilimab and chemotherapy in superior sqNSCLC continues to point out sturdy anti-tumor exercise and favorable security. The research is ongoing with the medical knowledge in squamous NSCLC persevering with to mature and can be disclosed sooner or later educational convention/journals.

Professor Caicun Zhou, Shanghai Pulmonary Hospital, acknowledged: “Lung most cancers is probably the most generally recognized most cancers and the main explanation for most cancers demise worldwide, of which non-small cell lung most cancers accounts for about 80%1. Lately, PD-1/PD-L1 inhibitors have proven promising efficacy in non-small cell lung most cancers2. Nonetheless, persistent response to immune checkpoint inhibitor monotherapy stays a problem in medical follow. IBI110 plus sintilimab point out promising antitumor exercise and a manageable security profile in untreated squamous non-small cell lung most cancers sufferers. Within the present 20 sufferers, the ORR reached 80% and the 12-month PFS price was 60%, which warrants additional investigation into the protection and efficacy of IBI110 mixture remedy on this indication.”

Dr. Hui Zhou, Senior Vice President of Innovent, acknowledged: “We’re happy to current our medical growth updates on the 2022 ESMO-IO Assembly. IBI110 together with sintilimab demonstrated encouraging efficacy and security knowledge in sqNSCLC. We’ll proceed to offer updates on the PoC knowledge for IBI110 and plan to provoke pivotal medical research. As immunotherapy strikes into the following period, we’re actively advancing the event of next-generation immune checkpoint inhibitors, amongst which IBI110 represents a high-potential LAG-3 asset, which we hope will profit sufferers in want quickly.”

To study extra about Innovent’s R&D updates and actions, please go to https://investor.innoventbio.com/cn/traders/webcasts-and-presentations/.

About IBI110

IBI110 is an IgG4κ recombinant human anti-LAG-3 monoclonal antibody independently developed by Innovent Biologics. Primarily based on the mechanism of motion and preclinical knowledge of IBI110, it’s assumed that IBI110 can inhibit the immune checkpoint signaling to attain anti-tumor impact, which can additional enhance the efficacy of immunotherapy, overcome the first drug resistance, and overcome the drug resistance after anti-PD-1 /PD-L1 monoclonal antibody therapy3. Primarily based on the pressing medical wants, Innovent has carried out medical research to discover PK/PD traits of IBI110 single agent and mixed with sintilimab in people in addition to its efficacy and security in varied superior tumors. This medical trial (NCT04085185) is the primary in human medical research of IBI110.

About Innovent

Impressed by the spirit of “Begin with Integrity, Succeed via Motion,” Innovent’s mission is to develop, manufacture and commercialize high-quality biopharmaceutical merchandise which might be inexpensive to odd folks. Established in 2011, Innovent is dedicated to growing, manufacturing and commercializing high-quality progressive medicines for the therapy of most cancers, autoimmune illness, metabolic dysfunction and different main ailments. On October 31, 2018, Innovent was listed on the Primary Board of the Inventory Alternate of Hong Kong Restricted with the inventory code: 01801.HK.

Since its inception, Innovent has developed a totally built-in multi-functional platform which incorporates R&D, CMC (Chemistry, Manufacturing, and Controls), medical growth and commercialization capabilities. Leveraging the platform, the corporate has constructed a strong pipeline of 35 beneficial property within the fields of most cancers, metabolic dysfunction, autoimmune illness and different main therapeutic areas, with 8 permitted merchandise available on the market. These embrace: TYVYT® (sintilimab injection), BYVASDA®(bevacizumab biosimilar injection), SULINNO® (adalimumab biosimilar injection), HALPRYZA®(rituximab biosimilar injection), Pemazyre®(pemigatinib oral inhibitor), olverembatinib (BCR ABL TKI), Cyramza® (ramucirumab) and selpercatinib. An extra 2 property are underneath NMPA NDA evaluation, 5 property are in Part 3 or pivotal medical trials, and 20 extra molecules are in medical research.

Innovent has constructed a global crew with superior expertise in high-end organic drug growth and commercialization, together with many world consultants. The corporate has additionally entered into strategic collaborations with Eli Lilly and Firm, Sanofi, Adimab, Incyte, MD Anderson Most cancers Heart and different worldwide companions. Innovent strives to work with many collaborators to assist advance China’s biopharmaceutical trade, enhance drug availability and improve the standard of the sufferers’ lives. For extra info, please go to: www.innoventbio.com and www.linkedin.com/firm/innovent-biologics/.

Observe:

TYVYT® (sintilimab injection) just isn’t an permitted product in the US.

BYVASDA® (bevacizumab biosimilar injection), SULINNO®, and HALPRYZA® (rituximab biosimilar injection) are usually not permitted merchandise in the US.

TYVYT® (sintilimab injection, Innovent)

BYVASDA® (bevacizumab biosimilar injection, Innovent)

HALPRYZA® (rituximab biosimilar injection, Innovent)

SULINNO® (adalimumab biosimilar injection, Innovent)

Pemazyre® (pemigatinib oral inhibitor, Incyte Company). Pemazyre® was found by Incyte Company and licensed to Innovent for growth and commercialization in Mainland China, Hong Kong, Macau and Taiwan.

CYRAMZA® (ramucirumab, Eli Lilly). CYRAMZA® was found by Eli Lilly and licensed to Innovent for commercialization in Mainland China.

Selpercatinib (Eli Lilly). Selpercatinib was found by Eli Lilly and licensed to Innovent for commercialization in Mainland China.

Disclaimer:

1. The indications are nonetheless underneath medical research, which have not been permitted in China.
2. Innovent doesn’t suggest any off-label utilization.

Ahead-Trying Statements

This information launch could include sure forward-looking statements which might be, by their nature, topic to vital dangers and uncertainties. The phrases “anticipate”, “consider”, “estimate”, “count on”, “intend” and related expressions, as they relate to Innovent, are meant to determine sure of such forward-looking statements. Innovent doesn’t intend to replace these forward-looking statements usually.

These forward-looking statements are primarily based on the present beliefs, assumptions, expectations, estimates, projections and understandings of the administration of Innovent with respect to future occasions on the time these statements are made. These statements are usually not a assure of future developments and are topic to dangers, uncertainties and different elements, a few of that are past Innovent’s management and are troublesome to foretell. Consequently, precise outcomes could differ materially from info contained within the forward-looking statements on account of future adjustments or developments in our enterprise, Innovent’s aggressive atmosphere and political, financial, authorized and social circumstances.

Innovent, the Administrators and the workers of Innovent assume (a) no obligation to right or replace the forward-looking statements contained on this web site; and (b) no legal responsibility within the occasion that any of the forward-looking statements doesn’t materialize or become incorrect.

Reference

1 Sung H, Ferlay J, Siegel R L, et al. International most cancers statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 nations[J]. CA: a most cancers journal for clinicians, 2021, 71(3): 209-249.

2 中华医学会肺癌临床诊疗指南(2022版)

3 J Thorac Oncol. 2017 Could;12(5):814-823. 2. jco.2022.40.16_suppl.e2114

SOURCE Innovent Biologics

Innovent Presents Part Ib Scientific Information Replace of IBI110 (Anti-LAG-3 Monoclonal Antibody) on the 2022 European Society For Medical Oncology Immuno-Oncology

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